Glossary of Terms

Adjuvant:  Therapies such as Herceptin or endocrine therapy that is given after surgical removal of all the known macroscopic disease in order to prevent recurrence.

AIs:  Aromatase inhibitors (one type of anti-estrogen therapy used in ER+ breast cancers). They work by reducing estrogen synthesis by the aromatase enzyme in peripheral tissues such as fat and the adrenal glands.

ALND:  Axillary lymph node dissection – the part of the surgery in which the surgeon takes out all the lymph nodes under your arm on the side of the invasive cancer to properly stage your cancer.

Alopecia:  Alopecia means hair loss. Almost all IBC patients receiving chemotherapy experience this temporary side effect from anthracyclines and taxanes.

Angiogenesis:  Angiogenesis is the process of tumor cells influencing the formation of new blood vessels to gain enough oxygen and nutrients to grow. This is a necessary step once the tumor has formed a clump of cells more than a few millimeters in size. IBC is known to induce these pathways at an early time point during progression.

Anthracyclines:  A class of chemotherapy frequently used in breast cancer. These drugs work by damaging the DNA. Examples include Doxorubicin (Adriamycin), Epirubicin (Ellence) and Liposomal Doxorubicin (Doxil).

Autologous reconstruction:  A general term for reconstructions using tissue from your own body. Examples include DIEP and TRAM flaps. If IBC patients desire reconstruction, delayed autologous methods are often the only options since implant procedures are difficult to do on radiated skin.

Axilla:  Medical term for the armpit. There are lymph nodes there that are often the first sites of IBC spread beyond the breast, since the breast lymphatics drain to these nodes.

Bolus:  A material that may be placed on the chest wall during radiation. The function of a bolus is to deposit more of the radiation dose in the skin versus deeper into the body. It can be made out of a plastic-type of material or other flexible material.

Cellulitis:  A bacterial infection that can arise in the arms or elsewhere that can increase the risk for lymphedema. The symptoms include swelling, red skin, pain/tenderness, warmth. Importantly the redness can quickly spread and lead to sepsis and possible death if left untreated. Antibiotics are required either by IV or orally. Visit your doctor or emergency room if you think you have cellulitis.

Chemo brain:  A constellation of long-term mental symptoms that arise in cancer survivors after chemotherapy, such as memory problems, difficulty concentrating, difficulty in multi-tasking and learning new skills. Although these symptoms are common, everyone is affected to a different degree.

CPM:  Contralateral prophylactic mastectomy – this is when a woman with a tumor in one breast chooses to have the non-diseased breast removed to prevent recurrence or a second breast cancer.

CTC: Circulating tumor cells. CTCs are a research tool currently, useful in determining metastatic potential and perhaps molecular targets for therapy.

ctDNA: Circulating tumor DNA. This is cell-free DNA that is circulating in the blood that can be detected and sequenced to find mutations that can be targeted therapeutically. This is a promising research area, but not ready for prime-time in IBC care.

DIEP flap: DIEP stands for deep inferior epigastric perforator artery. It is a type of reconstruction using fat, skin, blood vessels from the lower abdomen, but no muscle tissue is used.

ER: Estrogen receptor is often shortened as ER. ER is one of 3 markers typically used on diagnostic and surgical specimens in breast cancer. ER binds to estrogen and mediates its growth effects in both normal and tumor cells.

Expanders: Immediate reconstruction methods with a plan to insert an implant later involves placement of an expander under the skin during the mastectomy. This is then filled with saline slowly to expand the skin sufficiently over several months prior to the next surgery to exchange expanders with the final implant. In IBC due to the amount of radiation to the skin, this method is not recommended due to high rates of failure and complications.

FDG-Avid: On a PET scan report, this term means the glucose tracer has been taken up at a level above background at that site. FDG-Avidity can mean tumor spread or be completely unrelated to cancer. Speak with your doctor about the interpretation of your report findings.

Febrile neutropenia: If low neutrophil count is accompanied with a fever (a sign of infection) then the symptom is referred to as febrile neutropenia.

FISH: Fluorescence In-Situ Hybridization, which is a method using a fluorescent probe to detect RNA molecules in tumor/normal tissues. By counting the signals in each cell you can tell whether a protein is overexpressed or not.

FNA: FNA stands for a fine needle aspiration. This is when a thin needle is used to do a small biopsy of a lymph node to determine whether there are any tumor cells present in the lymph node. If there are tumor cells in the lymph node, the node is counted as “positive”.

“Foobs”: A colloquial word for breast prosthesis. Some women who decide against reconstruction use prostheses to look more natural.

Genetic testing: If a woman has a significant family history of breast, ovarian and/or other cancers, she may be referred to a genetic counselor to consider testing for inherited mutations in cancer predisposition genes such as BRCA1 and BRCA2. Such results can be used for risk reduction and decision-making among the patient and their other family members, and also has potential therapeutic implications.

“Godzilla”: A term adopted by some patients for the drug Kadcyla (also known as T-DM1) due to its strong activity. Kadcyla is one of the first antibody-drug conjugates designed to be a targeted chemotherapy delivered to tumor cells overexpressing HER2.

Grade: The grade of a tumor tells you how aggressive it looks histologically. There are 3 potential grades – most IBCs are grade 2 or grade 3 (the most aggressive). This is distinct from stage.

Gy: When discussing radiation, Gy stands for Gray. It is a unit of measurement for the dose of radiation received.

HER2: Human epidermal growth factor 2, is the full name of the protein typically shortened as HER2. It Is frequently overexpressed in IBC, and a target for drugs such as Trastuzumab (Herceptin), or Pertuzumab (Perjeta). HER2 protein is on the membrane of tumor cells and signals to proliferation pathways to induce tumor growth and aggressiveness.

IBC: Inflammatory Breast Cancer. IBC is a clinical diagnosis of invasive breast cancer in the presence of the distinctive skin symptoms that can include redness, orange peel appearance (peau d’orange), ridging, pain in the breast, warmth, and swelling.

IDC: Invasive ductal carcinoma. This is the most common pathological diagnosis in IBC patients. It means that the tumor is invasive, and the tumor cells look like they came from the normal cells that line the ducts.

IHC: Immunohistochemistry – this is a method using antibodies to detect proteins in tumor sections. It is the standard method for determining ER, PR and HER2 status (although HER2 is also examined by FISH)

ILC: Invasive lobular carcinoma. This is a less common pathological diagnosis for IBC patients. It means that the tumor is invasive and looks like the cells in the milk-producing cells (lobules). Often lobular carcinomas have distant clinical behavior to ductal carcinomas.

Immunotherapy: Immunotherapy is a type of therapy being investigated in cancer that uses your body’s immune system to fight the cancer. Examples can include monoclonal antibodies, genetically engineered T cells and vaccines.

Latissimus dorsi flap reconstruction: This is a type of reconstruction that uses tissue from your upper back to construct the breast.

LE: LE stands for Lymphedema which is a swelling of the arm or even the upper body due to the inability to drain lymphatic fluid normally. This is an unfortunate side effect from lymph node removal and axillary radiation in a subset of breast cancer patients.

Local recurrence/loco-regional recurrence: When a recurrence develops either on the chest well near where the breast used to be, or in the axilla, the recurrence is termed as a local or loco-regional recurrence. This is in contrast to a distant recurrence which is a recurrence anywhere else (i.e. liver, lungs, brain, bones).

Lymphovascular invasion: This is a pathological term for the presence of tumor cells in lymphatic and blood vessels near the primary tumor. It is a sign of aggressiveness, since invasion of blood vessels is the first step in formation of distant metastasis.

Margins: After surgery, the goal is clean margins, ie no tumor on the edge of surgical specimen. If there is still tumor at the edge, then the margins are “dirty”. The goal of a curative surgery should always be clean margins, and if the surgeon does not feel this is likely to be possible, consultation with a multidisciplinary team is warranted to evaluate all the options for further treatment.

MRM: Modified Radical Mastectomy. This is the recommended form of surgery for IBC patients. It is sometimes also shortened online as “Mx”.

NED: No evidence of disease (ie on scans and physical exam)

Neoadjuvant (NACT): Chemotherapy/systemic therapy that is given before surgery. NACT is the shortened form of the term ‘Neoadjuvant Chemotherapy’. In IBC this is the standard approach because at diagnosis the breast is inoperable.

Neutropenia: Low numbers of neutrophila (a type of white blood cell), which can be a frequent side effect from some types of chemotherapy (such as doxorubicin).

NSM: Nipple-sparing mastectomy. This is a type of mastectomy in which the breast tissue is removed, but the nipple is conserved, usually in preparation for a subsequent reconstruction. In IBC because of skin involvement, this is not recommended. A non-skin-sparing mastectomy is the recommended surgery for IBC patients.

OS: Overall survival

Palliative care: Palliative care is the management of cancer related symptoms to improve quality of life. It does not mean that the doctor has given up on you or that you are soon to die. Unlike hospice care, which is only at the end-of-life, palliative care can be given alongside treatments known to be effective against the cancer, and should be part of IBC management from diagnosis onwards. The word palliative is often used in metastatic patients for therapies that are not given with the goal of cure, but for improving the patient’s quality of life – for example decreasing pain from bone metastasis.

Peripheral neuropathy: A side effect from taxane chemotherapy that refers to numbness, tingling or shooting pain in the fingers or toes.

pCR: Pathological complete response – when drugs are studied in the neoadjuvant setting, this means there is no residual cancer cells (alive) in the surgery sample when the pathologist examines it. There are a few variations on how it is defined i.e. just in the breast or whether the lymph nodes must also be free of cancer.

PFS: Progression-free survival – in trials in metastatic patients, this is the time in which the patient lives without their disease becoming worse.

PR: Can be either Progesterone Receptor, or Partial Response (to a chemotherapy). Progesterone receptor is similar to ER, in that it is a hormone receptor that is measured on tumor cells to subtype the disease and decide upon treatment options.

QOL: Quality of life

Radiation boosts: During radiation to the chest wall, there will be some sessions near the end that are focused on specific areas (such as the area around the scar line). This is done to make sure any stray residual cancer cells near the surgical margins are given extra dose to maximize the chances they are killed off.

Receptor: A protein that is located on the surface of a cell that binds to a hormone or growth factor. Some specific examples of relevance in IBC include the Estrogen Receptor (ER) and HER2.

SERM: Selective estrogen-receptor modulators. These are a type of endocrine therapy used in ER or PR positive breast cancer patients to reduce recurrence. Examples of SERMs that are used clinically include tamoxifen and raloxifene.

SERD: Selective estrogen receptor down-regulators. This is a type of endocrine therapy that works via degrading the estrogen receptor, therefore limiting the effects of estrogen. Examples of these drugs include Fulvestrant and ARN-810.

SSM: Skin-sparing mastectomy. This is a type of mastectomy in which some skin is not removed to make future reconstruction more straightforward. This is not recommended for IBC patients due to baseline skin involvement.

SLND: Sentinel lymph node dissection – This is not a recommended procedure for IBC patients, but is sometimes done at the time of surgery in other early breast cancers in which a blue and radioactive dye is injected into the breast and allowed to drain into the armpit (axilla). The nodes that are blue and/or radioactive are called the sentinel nodes and are the first lymph nodes that would be likely to harbor metastases if the cancer has developed that ability.

SRE: Skeletal-related events – in patients with bone metastases, one way of measuring the effectiveness of bone targeted agents (such as bisphosphonates) is to measure the time till a fracture or other serious event involving the bone like spinal cord compression. It can also relate to the time when radiation (or sometimes surgery) is necessary for pain relief.

SRS: Stereotactic radiosurgery. This is a focused type of radiation, used sometimes for brain or bone metastases. It can also be called Gamma Knife or Cyberknife.

Stage: The stage of a cancer means how far it has spread beyond the primary site. The earliest stage of IBC is IIIB, which means the tumor may have invaded the axillary nodes, but no distant organs. Stage IV means distant metastatic spread at diagnosis.

Taxanes: A class of chemotherapy that is frequently used in IBC. These drugs work via interfering with processes important in cell division. Examples include Paclitaxel (Taxol) and Docetaxel (Taxotere).

TNBC: Triple negative breast cancer (i.e. ER negative, PR negative and HER2 negative/not overexpressed). Sometimes this is also abbreviated TN-IBC for triple-negative IBC patients.

TNM staging: This is the usual method in which tumors are staged. T takes into account tumor size; N takes into account the number and location of positive lymph nodes, and M tells you whether you have distant metastases or not. By definition IBC patients are T4d. Most are N1-N3 due to lymph node involvement. If diagnosed with stage 4 disease (ie distant metastases) then M1 is the designation.

TRAM flap: A TRAM flao (transverse rectus abdominus muscle) reconstruction is a type of breast construction using tissue from your lower abdomen, including the rectus abdominus muscle.

Tri-modal therapy: This refers to the overall plan for IBC treatment involving all 3 modalities of cancer therapy – chemotherapy, surgery and radiation.

Tumor emboli/Dermal tumor emboli: One of the histological findings that is more common in IBC is the presence of nests of tumor cells in the deeper layer of the skin (the dermis).

WBR: Whole brain radiation

XRT: External-beam radiation, which is the usual kind for chest wall or whole breast radiation. The radiation beams are generated in a linear accelerator, i.e. outside the body.

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