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PLX-3397 + MK-3475 Dual Immunotherapy

Alternative Drug Names: PLX-3397 is also called Pexidartinib. MK-3475 is now Pembrolizumab (Keytruda brand in the US). Purpose of Trial: The purpose of this phase 1/2 study is to establish the safety of the combination of these 2 agents in any solid tumor, and in the...

Dual HER2 + Abraxane

Alternative Drug Names: Nab-Paclitaxel (Abraxane brand in the US), Trastuzumab (Herceptin is the brand in the US and abroad), Pertuzumab (Perjeta brand in the US and abroad) Purpose of Trial: The purpose of this phase 2 study is to evaluate the effectiveness of the 3...

Ruxolitinib + Paclitaxel IBC

Alternative Drug Names: Ruxolitinib (Jakafi brand in the US) was previously also known as INCB018242. Purpose of Trial: The purpose of this phase 1/2 study is 2-fold. In the first part of the study in metastatic breast cancer patients, the goal is to determine a safe...

Dual HER2 + chemo upfront IBC

Alternative Drug Names: Paclitaxel (Taxol brand in the US and abroad), Trastuzumab (Herceptin is the brand in the US and abroad), Pertuzumab (Perjeta brand in the US and abroad) Purpose of Trial: The purpose of this phase 2 study is to evaluate the effectiveness of...

Nintedanib IBC

Alternative Drug Names: Nintedanib was called BIBF 1120 (Ofev brand in the US) Purpose of Trial: The purpose of this phase 2 study is to evaluate the safety and efficacy of Nintedanib in the setting of metastatic IBC. Nintedanib is FDA approved outside of oncology,...
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